NCT06396468

Sevoflurane and Intravenous Anesthesia in Hypospadias Repair

Emergence Delirium in Pediatric Age Group: Comparison Between Sevoflurane and Intravenous Anesthesia in Hypospadias Repair: A Randomized Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 1 Year – 8 Years
• Healthy volunteers: Not accepted

Summary

Emergence agitation (EA), a phenomenon observed at the time of recovery from general anesthesia (GA).The cause of ED appears to be multifactorial in origin. Use of volatile anesthetics, prolonged duration and type of surgery, pain, and rapid emergence are some factors known to increase its incidence

Detailed description

The pathogenesis of postoperative EA is still undefined, but sevoflurane has intrinsic effects that may share in emergence agitation like its different electroencephalogram pattern from halothane, and its degradation to inorganic fluoride ions and compound A which may have a role in the occurrence of EA Sevoflurane now is the inhalational anaesthetic agent of choice for pediatrics, as it is non-pungent, with minimal airway irritation characters, and its cardiac adverse effects are minimal like cardiac depression and dysrhythmias. Total intravenous anesthesia (TIVA) using propofol and fentanyl appears to have a smooth recovery profile

Conditions

• Emergence Delirium
• Intravenous Anesthesia
• Sevoflurane

Interventions

Type	Name	Description
DRUG	sevoflurane	sevoflurane (1-1.2 MAC)
DRUG	propofol	100-400 mcg/kg /min of propofol

Timeline

• Start date: 2024-03-01
• Primary completion: 2024-06-26
• Completion: 2024-07-26
• First posted: 2024-05-02
• Last updated: 2024-05-02

Locations

1 site across 1 country: Egypt