NCT06385301

Exercise Performance on Ambient Air vs. Low-Flow Oxygen Therapy With Chronic Lung Diseases

Exercise Performance on Ambient Air vs. Commonly Prescribed Nasal Low Oxygen Therapy - a Non-Inferiority Trial in Patients With Exercise Induced Desaturation Due to Chronic Lung Diseases

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators aim to study the effect of SOT in subjects with chronic lung disease in submaximal exercise.

Detailed description

Participants with lung disease who live in Switzerland will have 6-minute walk distance (6MWD) test with and without SOT at approximately 3l/min via nasal cannula according to a randomized cross-over design. The trial aims to test that the 6MWD with SOT is non-inferior to a 6MWD in the same participant under ambient air. Our effect size was estimated with a difference of less or equal to 35m compared under SOT compared to ambient air.

Conditions

• Lung Disease Chronic
• Lung Diseases, Interstitial
• Lung Diseases, Obstructive

Interventions

Type	Name	Description
OTHER	6-minute walk distance (6MWD) test on ambient air	6-minute walk distance (6MWD) test will be performed on ambient air according to clinical standards
OTHER	6-minute walk distance test with supplemental oxygen (approximately 3l/min, nasal)	6-minute walk distance (6MWD) test will be performed according to clinical standards additionally with supplemental oxygen therapy (approximately 3l/min, nasal)

Timeline

• Start date: 2024-05-01
• Primary completion: 2025-07-01
• Completion: 2025-07-01
• First posted: 2024-04-26
• Last updated: 2025-12-10

Locations

1 site across 1 country: Switzerland