NCT06384456

Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following DRF Fixation

The Effect of Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - the TRADR Study

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).

Conditions

• Distal Radius Fractures

Interventions

Type	Name	Description
DRUG	Topical TRanexamic Acid	10mL of 100mg/mL TXA will be administered into the surgical wound prior closure.
DRUG	Placebo	10mL of 100mg/mL normal saline will be administered into the surgical wound prior closure.

Timeline

• Start date: 2025-03-01
• Primary completion: 2026-06-01
• Completion: 2026-09-01
• First posted: 2024-04-25
• Last updated: 2025-03-28

Locations

1 site across 1 country: Canada