NCT06373562

Effect of Hypoxic Exposure on Blood Variables in Elite Wrestlers

The Influence of Sports and Hypoxic Training on the Regeneration and Adaptation of Skeletal Muscles to Exercise in Wrestlers.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Poznan University of Physical Education · Academic / Other
• Sex: Male
• Age: —
• Healthy volunteers: Accepted

Summary

Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers participating only in sports training. The hypoxic group lived and slept in hypoxic rooms. During the camp, all wrestlers followed the same training schedule and diet. In the blood were determined levels of creatine kinase (CK), C-reactive protein (hsCRP) concentration, nitric oxide (NO), morphology, reticulocytes, lipid profile, and ferritin. Also vascular endothelial growth factor (VEGF, VEGFR2, and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined.

Detailed description

Hypoxia exposure applied to professional athletes has attracted attention and scientific debate due to its effects on improving physiological response through cardiovascular and hematological mechanisms. Presently, hypoxic training programs are developed to improve exercise performance in athletes, a useful training method for athletes that may improve their performance in future sea-level competitions. 12 males were divided into the hypoxic (H) and control (C) groups. Group H was living and sleeping in hypoxic rooms (method live high-train low) for 8-14h/d (FiO2≈14%). The implementation of the project was intended to: 1) assess the dynamics of changes in the concentration of pro-inflammatory indicators and hematopoiesis in athletes to variable training loads and hypoxia, 2) explain the usefulness of hypoxic exposure in adaptation to physical exercise, 3) observe the length of the hypoxic cycle necessary to maintain the effect of high-altitude training. In the blood serum the level of basic biochemical indicators of fatigue related to muscle damage, inflammation, and energy deficit, i.e. total creatine kinase (CK) activity, C-reactive protein (hsCRP) concentration, nitric oxide (NO). Moreover, basic hematological indicators: morphology, reticulocytes, lipid profile, and ferritin. Also, angiogenesis regulators: vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR2 and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined using a body analyzer. Further investigations into hypoxia methods while considering individual capabilities are necessary for gaining deeper insights, into how hypoxia affects blood count and different blood variables among athletes.

Conditions

• Hypoxia

Interventions

Type	Name	Description
OTHER	hypoxia	The athletes were living in hypoxic rooms, which could simulate a selected altitude above sea level.

Timeline

• Start date: 2013-12-02
• Primary completion: 2013-12-18
• Completion: 2013-12-18
• First posted: 2024-04-18
• Last updated: 2025-01-17