NCT06372639

Characterization and Modulation of Traumatic Memories in PTSD Patients Using TMS

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Tel Aviv University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Characterization and modulation of traumatic memories in PTSD patients using TMS.

Detailed description

Study goals: 1. Characterization of the cortical brain regions that are suitable for effective modulation with TMS, which has the highest connectivity to the sub-cortical regions that are in the strongest connectivity with areas that directly contribute to the formation and preservation of intrusive traumatic memories. 2. Examine the modulation of those cortical brain regions with TMS, while deliberately re-activating an intrusive traumatic memory, on the clinical symptoms of PTSD patients.

Conditions

• Post Traumatic Stress Disorder

Interventions

Type	Name	Description
DEVICE	Trans-Cranial Magnetic Stimulation	Brain stimulation by the TMS device will be given after a deliberate memory re-activation, using repetitive pulses at 1Hz frequency for 15 minutes, the target area will be determined based on an fMRI scan in the resting state of the subject.

Timeline

• Start date: 2022-02-23
• Primary completion: 2024-10-24
• Completion: 2024-10-24
• First posted: 2024-04-18
• Last updated: 2024-11-01

Locations

1 site across 1 country: Israel