NCT06366412

Dexmedetomidine on Postoperative Cognitive Dysfunction and Serum Tau-217 Protein.

Effect of Dexmedetomidine on Serum Tau-217 Protein as a Biomarker for Post-operative Cognitive Dysfunction in Elderly Patients.

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 94 (estimated)
• Sponsor: Minia University Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

To assess the effect of Dexmedetomidine on serum Tau-217 protein and its relation to the incidence and severity of postoperative cognitive dysfunction in elderly patients undergoing major surgery under general anesthesia.

Detailed description

to assess the effect of dexmedetomidine on serum Tau-217 protein through measuring serum Tau-217 protein preoperative and postoperative period and comparing the 2 measurements , assessing the cognitive dysfunction in the elderly patients and comparing the correlation between the cognitive dysfunction with serum tau-217 level also assessing the neuroprotective effect of dexmedetomidine on postoperative cognitive dysfunction and its relation with serum Tau-217 level.

Conditions

• Cognitive Impairment

Interventions

Type	Name	Description
DRUG	Dexmedetomidine Hydrochloride	dexmedetomidine effect in preventing postoperative cognitive dysfunction on elderly patients undergoing major surgery guided with serum Tau-217 protein.
OTHER	normal saline	normal saline will be administrated in placebo group

Timeline

• Start date: 2024-04-01
• Primary completion: 2025-03-01
• Completion: 2026-03-01
• First posted: 2024-04-15
• Last updated: 2024-04-15

Locations

1 site across 1 country: Egypt