NCT06333236

Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: ASST Santi Paolo e Carlo · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Aim of this study is to investigate the administration effects of the combination of citicoline 40mg/ml and nicotinamide 15mg/ml oral solution (Kron®) on short term improvement in inner retinal function, bioelectrical activity of the visual cortex and visual function.

Detailed description

Prospective, masked, randomized placebo-controlled study to evalute the offect of the oral solution Kron® (citicoline 40mg/ml and nicotinamide 15mg/ml) on patients with a diagnosis of open angle glaucoma and risk of glaucoma progression. Glaucomatous patients with a diagnosis of open angle glaucoma and risk of glaucoma progression who meet the study criteria will be enrolled and randomly assign to the following two arms: 1. Treatment group (TG): 20 patients will receive Citicoline 40 mg/ml + Nicotinamide 15 mg/ml oral solution for 3 months (10 ml/day) 2. Control group (CG): 10 patients will be evaluated as control Once recruited, a clinical evaluator will perform a comprehensive ophthalmologic evaluation at baseline, week 6 and week 12. The following examinations will be done in the following sequence: * Visual acuity * Slit lamp evaluation * PERG * PEV pattern * Tonometry * Visual field * Optical Coherence Tomography * Dilated Fundus examination

Conditions

• Glaucoma

Interventions

Type	Name	Description
OTHER	Food for Special Medical Purposes: Kron®	Citicoline 40mg/ml + Nicotinamide 15 mg/ml oral solution

Timeline

• Start date: 2025-04-10
• Primary completion: 2025-07-15
• Completion: 2025-09-14
• First posted: 2024-03-27
• Last updated: 2025-09-22

Locations

2 sites across 1 country: Italy