NCT06332365

Evaluating Treatment Efficacy in Oral Lichen Planus: The Role of Salivary Biomarkers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Pia Lopez Jornet · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Lichen planus, a chronic autoimmune mucocutaneous disorder, affects 0.5% to 2.2% of diverse populations. The treatment for oral lichen planus (OLP) includes a range of options, both topical and systemic therapies. Recent research has highlighted the potential of hyaluronic acid as a drug alternative, potentially offering effective management for OLP and alleviating the discomfort of this chronic condition. The objective was to assess the impact of topical hyaluronic acid on salivary oxidative stress markers in individuals suffering from oral lichen planus

Detailed description

Interventional (Clinical Trial) Actual Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Care Provider, Outcomes Assessor) Masking Description: The clinical outcomes were assessed by an investigator masked about the treatment modality that has been used Primary Purpose: Treatment Pain , quality of life the study on oral lichen planus, three treatment groups were established: Group I: Received a combination of 0.1% hyaluronic acid and 0.2% triamcinolone acetonide. Group II: Was treated solely with 0.2% triamcinolone acetonide. Group III: Received only 0.1% hyaluronic acid. These groups were designed to evaluate and compare the efficacy of different treatments in patients with oral lichen planus.

Conditions

• Oral Lichen Planus
• Oral Lichen Planus Related Stress

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Acetonide triamcinolone 0.2% +hyaluronicacid 1%	topical application cream form twice a day for 4 weeks
DRUG	Corticoid Acetonide triamcinolone 0.2%	topical application cream form twice a day for 4 weeks
DRUG	Hyaluronic acid 1%	topical application cream form twice a day for 4 weeks

Timeline

• Start date: 2022-01-03
• Primary completion: 2023-12-15
• Completion: 2024-02-19
• First posted: 2024-03-27
• Last updated: 2024-03-27

Locations

1 site across 1 country: Spain