NCT06330519

Enhancing Anaesthetic Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Comparative Randomized Controlled Trial

"Impact of Different Techniques on the Efficacy of Anaesthesia in Mandibular Molars With Acute Irreversible Pulpitis: A Randomized Controlled Trial"

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 188 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 25 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to assess the effect of * Preoperative intraligamentary corticosteroids injection * Cryotherapy which is cold application on : * Hard tooth structure ( crown of the tooth ) * Soft tissue overlying roots on the efficacy of the inferior alveolar nerve block anaesthesia in patients with mandibular molars with symptomatic irreversible pulpitis. The main question it aims to answer are: • Does intraligamentary dexamethazone injection increase the success rate of inferior alveolar nerve block without the need for oral premedication. Participants will describe their preoperative pain level to the investigator and describe their pain level during the treatment. Researchers will compare cryotherapy to see if it increases the success rate of inferior alveolar nerve block.

Conditions

• Pulpitis - Irreversible

Interventions

Type	Name	Description
DRUG	Dexamethasone sodium phosphate injection	Patients receive 0.8ml of dexamethazone by periodontal ligament injection 30 minutes before the inferior alveolar nerve block
OTHER	1,1,1,2 tetrafluoroethane	EndoIce (1,1,1,2 tetrafluoroethane) applied on the buccal, lingual (3 s/surface), and occlusal surfaces (4 s) for a total of 10 s then standard IANB was administered
OTHER	intraoral soft tissue cryotherapy	Small ice packs (wrapped in sterile gauze) placed intraorally in the mouth on the vestibular surface of the treated tooth for 5 minutes then standard IANB was administered

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-03-01
• Completion: 2024-03-30
• First posted: 2024-03-26
• Last updated: 2025-05-09

Locations

1 site across 1 country: Egypt