NCT06318312

Effects of Hypoxia on Cognitive Performance

Effects of Different Hypoxia Exposures on Cognitive Performance in Healthy Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University of Castilla-La Mancha · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to determine the effects of different hypoxia exposures (FiO2 = 11%, 13%, 15%, and 21%) on cognitive performance in healthy adults. The main questions it aims to answer are: * What is the best hypoxia exposure to improve reaction time, anticipation, attention and memory tasks? * Which hypoxia exposure causes the greatest detriments in cognitive function?

Detailed description

Participants will completed four trials in a single-blinded crossover randomised control trial. In the first session, individuals familiarised with the different cognitive tests and hypoxic exposures. In the next four experimental trials (separated by 1 week), participants arrived at the laboratory and rested in a seated for 10 min. The vital signs (i.e., SpO2, HR, blood pressure) and Lake Louise Score were recorded prior to mask placed and start with in one of the four conditions: a) PLA/NOR, b) FiO2=15%, c) FiO2=13% or FiO2=11%. In this hypoxic condition the participant will spend a total of 45 min, of which 30 min was at rest, and the other 15 min was performing the cognitive tasks (i.e., memory test, go/no-go test, eriksen flanker test, anticipation task and reaction time test).

Conditions

• Hypoxia

Interventions

Type	Name	Description
OTHER	Hypoxia	Hypoxic exposure: FiO2 = 11% Hypoxic exposure: FiO2 = 13% Hypoxic exposure: FiO2 = 15% Hypoxic exposure / placebo: FiO2 = 21%

Timeline

• Start date: 2024-03-20
• Primary completion: 2024-04-05
• Completion: 2024-04-26
• First posted: 2024-03-19
• Last updated: 2024-05-08

Locations

1 site across 1 country: Spain