NCT06307340

Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulant-opioid polysubstance use. The study aims to adapt STAIR-NT to a massed treatment schedule. Once an adapted protocol is complete, it will be tested for feasibility, acceptability, and short-term polysubstance and PTSD symptomology outcomes in a pilot randomized control trial (RCT) of 80 participants. Participants who screen eligible and consent will be randomized 1:1 to the adapted STAIR-NT intervention or treatment as usual (TAU) using randomization blocks of two and two and four via a computer-generated randomization sequence. Participants assigned to the intervention will receive the adapted massed delivery of STAIR-NT by trained counselors.

Conditions

• Polysubstance Abuse
• Posttraumatic Stress Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Skills Training in Affective and Interpersonal Regulation with Narrative Therapy (STAIR-NT)	Adapted version of evidence-based behavioral PTSD intervention.
BEHAVIORAL	Treatment as Usual	Treatment as usual.

Timeline

• Start date: 2024-10-14
• Primary completion: 2026-06-30
• Completion: 2026-09-30
• First posted: 2024-03-12
• Last updated: 2026-03-12

Locations

3 sites across 1 country: United States