NCT06294106

eTMS for Veterans and First Responders With PTSD

Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Virginia Polytechnic Institute and State University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.

Detailed description

Veterans and first responders diagnosed with PTSD will be studied to evaluate safety and efficacy of an EEG personalized TMS paradigm. All participants will undergo 2 days of extensive testing prior to eTMS application and 2 days of testing after. Testing will include MRI, OPM, EEG, behavioral tasks, questionnaires, and an EEG sleep study.

Conditions

• Post Traumatic Stress Disorder

Interventions

Type	Name	Description
DEVICE	Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)	EEG is utilized to determine a personalized frequency to then apply TMS to the frontal lobe.

Timeline

• Start date: 2024-06-10
• Primary completion: 2026-04-01
• Completion: 2026-04-01
• First posted: 2024-03-05
• Last updated: 2025-08-11

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study