NCT06292104

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 350 (estimated)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 14 Years
• Healthy volunteers: Accepted

Summary

This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.

Detailed description

This comprehensive multimodality deep phenotyping will improve the diagnostic approach, inform the development of new treatments, and allow the targeting of therapies to specific POTS patients. The investigators will further identify the diagnostic tools, biomarkers, and clinical outcome measures most relevant to defining the disorder in clinical practice. The specific aim is to (1) Define clinical POTS classifications from multimodal clinical and laboratory data, (2) address exercise tolerance in POTS using metabolomic assessments, (3) evaluate novel POTS-specific patient outcome measures and (4) evaluate one year outcome data for POTS Specific research tests will include blood work (for immunophenotyping and neurohormonal assessments), autonomic function testing, skin biopsy (to evaluate intraepidermal nerve fiber density), CO (Carbon Monoxide) rebreathing (for quantitative measurement of plasma volume and red blood cell mass), patient surveys (to characterize symptom profile and disease impact). Blood biosamples will be stored as a repository for future research questions.

Conditions

• Postural Orthostatic Tachycardia Syndrome

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	multimodal diagnostic testing	Serological testing, cardiac MRI, skin biopsy, cardiovascular testing, blood volume measurements

Timeline

• Start date: 2024-03-05
• Primary completion: 2028-12-01
• Completion: 2029-01-01
• First posted: 2024-03-04
• Last updated: 2025-06-27

Locations

1 site across 1 country: United States