NCT06270485

Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 1 Day – 5 Years
• Healthy volunteers: Not accepted

Summary

Interventional Trial to determine the Effect of different PEEP levels on Cardiac output and right-ventricular function in mechanically ventilated children \< 5 years of age with congenital heart disease.

Detailed description

Different PEEP-levels will be applied during invasive mechanical ventilation to describe Cardio-pulmonary interactions in children with congenital heart disease (CHD). An additional trial with the same study protocol is planned in a cohort of children with primarily pulmonary disease without CHD after completion of this trial. Esophageal pressure-monitoring, Ultrasound, respiratory mechanics and electrical impedance tomography will be used

Conditions

• Ventilation Therapy; Complications
• Congenital Heart Disease
• Children, Only
• Hemodynamic Instability

Interventions

Type	Name	Description
PROCEDURE	PEEP	Application of different PEEP-Levels during invasive mechanical ventilation

Timeline

• Start date: 2023-11-27
• Primary completion: 2024-07-15
• Completion: 2024-11-22
• First posted: 2024-02-21
• Last updated: 2025-09-19

Locations

2 sites across 2 countries: Germany, Netherlands