NCT06241924

Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range. The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

Detailed description

In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed. The local field potentials (LFPs) will be collected during the same motor task in : i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.

Conditions

• Parkinson Disease
• Epilepsy

Interventions

Type	Name	Description
PROCEDURE	High Resolution Electroencephalogram (EEG-HR)	Local field potentials (LFP) recording using EEG-HR
PROCEDURE	Stereo-electro-encephalography (SEEG)	Local field potentials (LFP) recording using sEEG

Timeline

• Start date: 2024-02-05
• Primary completion: 2027-02-05
• Completion: 2027-02-05
• First posted: 2024-02-05
• Last updated: 2025-07-23

Locations

1 site across 1 country: France