NCT06237569

Dose Low Dose Ketamine in Casesarian

Effects of Low Dose ketamıne on Postpartum Depression During Caesarean Sections

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Inonu University · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The results of ketamine, ketamine and midazolom and placebo can be copied after birth in cesareans subjected to spinal anesthesia.

Detailed description

Postpartum depression will be evaluated by dividing the patients into 3 groups: group 1 as ketamine, group 2 as ketamine and midasom, and group 3 as placebo group.

Conditions

• Postoperative Pain
• Postpartum Depression

Interventions

Type	Name	Description
DRUG	Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia	A single dose of 0.5 mg/kg IV diluted to 5 ml with 0.9% saline was planned to be administered simultaneously to the Ketamine Group (GROUP 1), ketamine and midazolam within 5 minutes after the newborn umbilical cord was clamped (Group 2). After midazolam 0.03 mg/kg is given, a single dose IV bolus of 0.5 mg/kg diluted to 5 ml with 0.9% saline will be administered. Patients experience dizziness, hallucinations, nausea, headache, vomiting, diplopia and blurred vision, the time until the first analgesic request; Depression parameters will be evaluated with the Edinburgh Postpartum Depression Scale (EPDS) in all patients before cesarean section and at the 1st, 2nd and 4th weeks after birth.

Timeline

• Start date: 2024-06-01
• Primary completion: 2024-08-01
• Completion: 2024-09-01
• First posted: 2024-02-01
• Last updated: 2024-02-01

Locations

1 site across 1 country: Turkey (Türkiye)