NCT06217679

Comparing the Effects of Different Types of Exercise on Glucose Handling

Comparing the Effects of Different Types of Exercise on Glucose Handling and Muscle Metabolism in Young Males and Females

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Waterloo · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females. The exercise modalities that will be compared include: a high intensity interval exercise (HIIE) protocol, a moderate intensity continuous exercise (MICE) protocol and a low-load, high-repetition (LL-HR) resistance exercise protocol.

Detailed description

The purpose of this study is to compare the effects of different exercise modalities (High intensity interval exercise, Moderate intensity continuous exercise, and Low-load-high repetition resistance exercise) on blood sugar control in young healthy, males and females. To test this theory, a sugar challenge (oral glucose tolerance test - OGTT) will be performed during the pre-testing visit to determine the baseline blood sugar response. An OGTT will also be performed 2 hours after each single exercise session to determine how each type of exercise affects the blood sugar response. Investigators will take multiple blood samples throughout the trial to allow us to measure blood sugar, insulin and concentrations and oxidative stress. Muscle biopsies will be taken before and after each exercise bout so that investigators can examine the underlying mechanisms that contribute to the effectiveness of the different types of exercise on blood sugar control. Investigators will also use an ultrasound to measure factors related to of cardiovascular health such as artery stress and vascular conductance during the exercise bouts. Direct benefits of this study include characterizing sex differences of blood sugar handling after single exercise sessions. This study could have direct benefits on deterring the effectiveness of different forms of exercise on blood sugar levels.

Conditions

• Glycemic Control
• Insulin Sensitivity
• Sex Differences

Interventions

Type	Name	Description
OTHER	Control Oral Glucose Tolerance Test	control oral glucose tolerance test
OTHER	Mixed Exercise	exercise performed in randomized order

Timeline

• Start date: 2018-05-01
• Primary completion: 2019-10-31
• Completion: 2019-10-31
• First posted: 2024-01-22
• Last updated: 2024-02-06

Locations

1 site across 1 country: Canada