NCT06201910

Evaluation of Peripartum Blood Loss and Postpartum Anaemia in Macrosomia & Gemini

Retrospective Evaluation of Peripartum Blood Loss and Postpartum Anaemia With Respect to Fetal Macrosomia and Gemini

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 575 (actual)
• Sponsor: Goethe University · Academic / Other
• Sex: Female
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Anaemia in pregnant women occurs at a haemoglobin (Hb) concentration \<11 g/dL and treatment is essential to prevent increased maternal morbidity, fetal morbidity and mortality. Studies show a distinct risk of haemorrhage in pregnant women due to increased uterine dilatation, due to twins or macrosomic singletons. Currently, prepartum anaemia management, the influence of anaemia and the administration of foreign blood concentrates are insufficiently studied. The investigators intend to conduct a monocentric retrospective analysis of this subcohort.

Detailed description

Patient blood management is essentially based on three pillars, and a meta-analysis has already shown that consistent use can reduce transfusions and mortality. The WHO defines anaemia in pregnant patients as a haemoglobin (Hb) concentration \<11 g/dl. Treatment of iron deficiency anaemia is essential because data show that iron deficiency anaemia is associated with increased maternal morbidity, fetal morbidity and mortality. Studies show a separate risk of bleeding in pregnant women due to increased uterine prolapse, for example in twin pregnancies or macrosomic singletons. At present, the prepartum anaemia management of patients, the influence of anaemia and the administration of foreign blood concentrates are insufficiently studied, which the investigators intend to investigate.

Conditions

• Bloodloss in Pregnancy

Interventions

Type	Name	Description
OTHER	Observation of Blood loss	Retrospetive observation of bloodloss and RBC transfusions.

Timeline

• Start date: 2023-10-01
• Primary completion: 2025-01-01
• Completion: 2025-02-01
• First posted: 2024-01-11
• Last updated: 2025-05-07

Locations

2 sites across 1 country: Germany