NCT06186050

Effects of a High-fat Meal on Exercise-mediated Sympatholysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Guelph · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The goal of this trial is to examine the effects of a single high-fat meal with or without the co-ingestion of dietary nitrate on exercise-mediated sympatholysis. The main questions it aims to answer are: 1. What are the mechanisms responsible for reduced exercise-mediated sympatholysis following a high-fat meal 2. Can dietary nitrate prevent the declines in exercise-mediated sympatholysis Participants will be asked to complete three study visits in a randomized order: 1. Low-fat meal 2. High-fat meal 3. High-fat meal plus dietary nitrate Exercise-mediated sympatholysis will be measured using Doppler ultrasound via a protocol involving rhythmic handgrip exercise and a lower body negative pressure stimulus. Sympatholysis will be assessed before each meal, and at 1, 2, and 3 hours post-prandial.

Conditions

• Diet, Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Beetroot drink	Drink containing 10g of beetroot powder in 250 mL cold tap water
DIETARY_SUPPLEMENT	Placebo	Mio flavouring in 250 mL cold tap water. Trace amounts of sugar and sodium were added to match the content in the beetroot supplement
DIETARY_SUPPLEMENT	Control	Low-fat meal with cornflakes, greek yogurt, skim milk, and orange juice

Timeline

• Start date: 2024-01-08
• Primary completion: 2024-07-30
• Completion: 2024-07-30
• First posted: 2023-12-29
• Last updated: 2024-09-19

Locations

1 site across 1 country: Canada