NCT06164535

The Effects of DPPIs on Cognitive Function of Diabetic Patients

The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 105 (estimated)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 45 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This is a single-center, randomized controlled clinical trial with a parallel-group design conducted at Minia University hospital.

Detailed description

All patients admitted to Diabetes clinics of Minia University Hospital, will be screened for the eligibility criteria. diabetic patients (aged above 50 years) with uncontrolled diabetes on oral hypoglycemic drugs. 105 patients will be enrolled and randomized into three groups. Group I=35 T2DM patients given DPP4Is Group II=35 T2DM patients given DPP4Is and metformin. Group III=35 patients will be given placebo (only adjust their drugs to control blood glucose level)

Conditions

• Cognitive Impairment

Interventions

Type	Name	Description
DRUG	Control group	35 T2DM patients will be given placebo (only adjust their drugs to control blood glucose level)
DRUG	DPP-4 inhibitor group	35 T2DM patients will be given DPP-4 I once or twice daily
DRUG	DPP-4 inhibitor + metformin group	35 T2DM patients will be given DPP-4 I + metformin once or twice daily

Timeline

• Start date: 2023-12-30
• Primary completion: 2024-06-30
• Completion: 2024-07-15
• First posted: 2023-12-11
• Last updated: 2023-12-11

Locations

1 site across 1 country: Egypt