NCT06155786

Cognitive Effects of tDCS and tRNS in Schizophrenia

Cognitive Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Random Noise Stimulation (tRNS) in Schizophrenia: A Random, Crossover Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: The National Brain Mapping Laboratory (NBML) · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the cognitive effects of different electrical stimulation modalities, such as transcranial direct and random-noise stimulation over the dorsolateral prefrontal cortex, in schizophrenia.

Conditions

• Schizophrenia
• Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	transcranial direct current stimulation (tDCS) active stimulator	In tDCS the electrical current is applied directly between electrodes mounted on the head which can can de-or hyperpolarizes resting membrane potential and thereby modulate cortical excitability
DEVICE	transcranial random noise stimulation (tRNS)	Here, an alternating electrical current is applied at a mix of frequencies it is called transcranial random noise stimulation (tRNS), which can be delivered in low (between 0.1-100 Hz) or high (between 101-640 Hz) frequency stimulation
DEVICE	transcranial direct current stimulation (tDCS) sham stimulator	Here a sham electrical current is applied directly between electrodes mounted on the head which can can de-or hyperpolarizes resting membrane potential and thereby modulate cortical excitability

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-11-01
• Completion: 2024-07-22
• First posted: 2023-12-04
• Last updated: 2026-03-18

Locations

2 sites across 1 country: Iran