NCT06140758

Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model

Evaluation of the Anticaries Efficacy of Various Dentifrice Formulations Using an In-situ Model

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Procter and Gamble · Industry
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The primary objective is to compare the remineralization and demineralization inhibition potential of early subsurface carious lesions in enamel in situ after rinsing with six different aqueous slurries of toothpaste formulations.

Conditions

• Caries

Interventions

Type	Name	Description
DRUG	Oral-B 1450 ppm Fluoride (1.16% sodium monofluorophosphate) Dentifrice	Each subject will use this product during one of the six treatment periods in the crossover study design.
DRUG	Colgate 1450 ppm Fluoride (1.16% sodium monofluorophosphate)Dentifrice	Each subject will use this product during one of the six treatment periods in the crossover study design.
DRUG	Toms of Maine 0 ppm Fluoride Dentifrice	Each subject will use this product during one of the six treatment periods in the crossover study design.
DRUG	Colgate 1450 ppm Fluoride (1.1% sodium monofluorophosphate) Dentifrice	Each subject will use this product during one of the six treatment periods in the crossover study design.
DRUG	1500 ppm MFP/CaCO3 1.16% sodium monofluorophosphate) Dentifrice	Each subject will use this product during one of the six treatment periods in the crossover study design.
DRUG	1100 ppm (0.454% Stannous fluoride) Dentifrice	Each subject will use this product during one of the six treatment periods in the crossover study design.

Timeline

• Start date: 2023-07-31
• Primary completion: 2023-12-11
• Completion: 2023-12-11
• First posted: 2023-11-20
• Last updated: 2024-02-29

Locations

1 site across 1 country: Australia