NCT06132529

A Study to Evaluate Biomarker Signature to Predict the Persistence of Post-traumatic Headache

Biomarker Signature to Predict the Persistence of Post-traumatic Headache

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 151 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to develop a model to help distinguish patients at high-risk for developing persistent post-traumatic headache from patients who experience headache recovery. Researchers will do this by comparing the brain images, clinical data, and speech of healthy controls to people who have been diagnosed with post-traumatic headache.

Conditions

• Post-Traumatic Headache
• Healthy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Brain Magnetic Resonance Imaging (MRI) Scan	Imaging of the brain
OTHER	Speech Sample	Recorded reading aloud of pre-written words and sentences
OTHER	Electronic Daily Headache Diary	Headache diary to provide information about headaches experience that day.

Timeline

• Start date: 2019-06-03
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2023-11-15
• Last updated: 2025-08-29

Locations

2 sites across 1 country: United States