NCT06119802

Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial Fibrillation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 10,000 (estimated)
• Sponsor: Yinglong Hou · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

To clarify the predictive effects of uric acid and superoxide dismutase as biomarkers of oxidative stress on atrial fibrillation, and to provide greater value for the diagnosis and prediction of atrial fibrillation. It provides a new idea for the prevention and treatment of atrial fibrillation.

Detailed description

In recent years, a growing number of reports have shown the importance of oxidative stress in the pathophysiological mechanism of AF. During oxidative stress, there is an imbalance between the production of pro-oxidant reactive species and the antioxidant defenses of the cell, and excessive oxidation leads to oxidative damage and cell death. Redox processes can lead to atrial fibrosis and cardiac remodeling , suggesting that strategies to address myocardial oxidative stress may constitute a reasonable approach for the treatment of AF. However, few studies have reported the relationship between comprehensive oxidative stress-related biomarkers and AF. The purpose of this study was to illuminate the relationship of several blood markers of oxidative stress with AF and to provide new clues for the prevention and treatment of AF.

Conditions

• Atrial Fibrillation
• Hyperuricemia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	atrial fibrillation	ECG of atrial fibrillation last more than 30 seconds.

Timeline

• Start date: 2022-01-01
• Primary completion: 2023-10-31
• Completion: 2024-04-30
• First posted: 2023-11-07
• Last updated: 2023-11-07

Locations

1 site across 1 country: China