NCT06115551

Fasting Mimicking Diet and Autophagy

Cellular Effects of Fasting Mimicking Diet In Humans: An Interventional, Randomized, Open Label, Parallel Assignment Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: L-Nutra Inc · Industry
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims to evaluates autophagy in circulating white blood cells from generally healthy human volunteers exposed to fasting mimicking diet (FMD), a 5-day dietary regimen.

Detailed description

Fasting-mimicking diet (FMD) was developed to mimic the endocrine and metabolic effects that water-only fasting, while providing a modest calories and essential nutrients. The health benefits of FMD are caused by several molecular mechanisms, including the reduction of body weight, ectopic fat storage, insulin levels, endogenous glucose production and IGF-1. Autophagy is a catabolic membrane-trafficking phenomenon observed in yeast and mammalian cells. Nutrient deprivation induces autophagy. Autophagy has been proposed to be a fundamental cellular process being linked to aging and the progression of age-related diseases. The objective of this study is to evaluate the effects of consuming two FMD formulations on the autophagy process in the cell.

Conditions

• Diet
• Autophagy

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Fasting Mimicking Diet	FMD is a 5-day low calorie fasting-mimicking diet.

Timeline

• Start date: 2023-05-02
• Primary completion: 2024-04-30
• Completion: 2024-04-30
• First posted: 2023-11-03
• Last updated: 2024-04-04

Locations

1 site across 1 country: United States