NCT06112093

Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches

Using Repetitive Transcranial Magnetic Stimulation to Manage Headaches and Improve Rehabilitation Outcomes in Mild Traumatic Brain Injury: A Longitudinal Study

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: State University of New York - Upstate Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effects commonly seen in medications, such as sleepiness and addiction. This study uses rTMS to manage chronic headaches to improve post-concussion symptoms and reduce the economic burden due to delayed recovery. This project aims to better identify biomarkers for diagnosis and prognosis and maximize recovery from mTBI.

Conditions

• Brain Concussion
• Mild Traumatic Brain Injury
• Headache
• Post-Concussion Symptoms

Interventions

Type	Name	Description
DEVICE	Repetitive Transcranial Magnetic Stimulation	rTMS will be used to regulate the motor cortex to reduce headaches and post-concussion symptoms.
DEVICE	Sham Repetitive Transcranial Magnetic Stimulation	Sham rTMS will be delivered by a sham coil as a comparator to the (active) rTMS. Sham rTMS will not change the brain function of the control group.

Timeline

• Start date: 2023-10-23
• Primary completion: 2026-10-23
• Completion: 2027-10-23
• First posted: 2023-11-01
• Last updated: 2025-10-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study