Trials / Recruiting
RecruitingNCT06090682
Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment
Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- Tianjin Huanhu Hospital · Academic / Other
- Sex
- All
- Age
- 75 Years
- Healthy volunteers
- Not accepted
Summary
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.
Detailed description
A variety of post-processing methods (VBM, SPM, CAT, LEAD-DBS, etc.) were used to analyze structural brain network images (sMRI, DTI) and functional brain network images (rs-fMRI, PET) based on connectomics, and combined with the changes of clinical symptoms before and after treatment. To study the mechanism of the influence of neural regulation on brain network, and further analyze how DBS and TMS improve the cognitive symptoms of PD patients from the perspective of brain connectomics, so as to explore the occurrence and development of Parkinson's disease with cognitive impairment and the possible improvement mechanism.According to the individual differences in clinical symptoms of different PD patients, better stimulation sites and the best brain network are sought to further guide the surgical plan, so as to obtain the best clinical treatment effect.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS) | We observed the changes in cognitive function of patients before and after different brain stimulation treatments, and further compared the effects of different brain stimulation treatments on cognitive function of PD patients and the related mechanisms according to whether DBS surgery was performed or TMS therapy was given only according to the surgical indications. |
Timeline
- Start date
- 2023-11-01
- Primary completion
- 2026-11-01
- Completion
- 2027-11-01
- First posted
- 2023-10-19
- Last updated
- 2023-10-19
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06090682. Inclusion in this directory is not an endorsement.