NCT06062472

Effect of Lactobacillus Paracasei PS23 on Improving Aging and Muscle Loss in the Elderly

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 119 (actual)
• Sponsor: Chi-Chang Huang · Academic / Other
• Sex: All
• Age: 65 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This study refers to the supplementation of PS23 in human experiments to help the elderly maintain muscle mass, delay muscle loss, promote physical activity, and delay the occurrence of disability and debilitation in elderly people.

Detailed description

Taiwan has become an aging society in recent years. There are important issues to attenuate aging and activate the potential capacity of elderly population. The physical function of middle-aged and older people will degenerate with age and produce age-related diseases. Common symptoms are organ function deterioration, and old age disability caused by malnutrition and muscle loss is also a common care problem. Therefore, how to prevent the complications of muscle loss is one of the important ten years of geriatric research. Although past research has been confirmed, it can improve the debilitating condition of the elderly through nutrition counseling and exercise intervention. However, there is not much in-depth discussion on how probiotics can improve muscle loss and delay symptoms in elderly people. Therefore, this study refers to the supplementation of PS23 in human experiments to help the elderly maintain muscle mass, delay muscle loss, promote physical activity, and delay the occurrence of disability and debilitation in elderly people. One hundred and twenty elderly people will be recruited and then divided into three groups with 40 people in each group: (A) placebo group, (B) PS23 probiotic group, (C) PS23-HT prebiotic group, supplemented for 12 weeks. The diet record, functional test and muscle mass will be carried out every six weeks after the start, to understand whether PS23 is effective in improving muscle loss and weakness in elderly people.

Conditions

• Elderly
• Muscle Loss
• Depression
• Anxiety

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotics	Lactobacillus paracasei PS23 will be used in this study
DIETARY_SUPPLEMENT	heat-treated of Lactobacillus paracasei HT-PS23	heat-treated probiotic capsule contain 10 billion of Lactobacillus paracasei, 2 caps daily use
DIETARY_SUPPLEMENT	Placebo	The placebo capsule contains microcrystalline cellulose, 2 caps daily use

Timeline

• Start date: 2023-08-08
• Primary completion: 2023-11-30
• Completion: 2023-12-31
• First posted: 2023-10-02
• Last updated: 2024-10-16

Locations

1 site across 1 country: Taiwan