NCT06039787

Exercise Training on Brain Insulin Responsiveness

Effects of One Exercise Training Session on Brain Insulin Responsiveness

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University Hospital Tuebingen · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.

Detailed description

Investigate one acute bout of exercise on the brain insulin responsiveness using functional magnetic resonance imaging in combination with intranasal insulin in healthy participants of normal-weight and overweight/obesity. Two single endurance exercise sessions with different intensities will be evaluated, namely moderate intensity continuous training (MICT) and high-intensity interval training (HIIT). This will be compared to a waiting control condition. In a cross-over design, investigators will compare cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT compared to a control condition without exercise. Cerebral response is defined as the cerebral blood flow and resting state functional connectivity in response to intranasal insulin. Secondary outcomes include changes in blood metabolites and proteins and changes in eating behavior.

Conditions

• Insulin Resistance
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	single bout of moderate intensity continuous training (MICT)	the MICT consists of 60 min continuous cycling
BEHAVIORAL	single bout of High Intensity Interval Training (HIIT)	HIIT consists of 10-min warm-up at the power output corresponding to 50% peak power output (PPO), 4 x 4-min intervals at a power output corresponding to 75% PPO with a 4-min active resting period at 30% PPO to recover
BEHAVIORAL	waiting control	sitting in a waiting room for 60 min

Timeline

• Start date: 2023-10-20
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2023-09-15
• Last updated: 2023-11-08

Locations

1 site across 1 country: Germany