NCT06033053

Real-time Neurofeedback Training of Fronto-limbic Regions Functional Connectivity

Real-time Neurofeedback Training of Fronto-limbic Areas Functional Connectivity to Reduce Arousal

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This is randomized active-sham group controlled between-subject real-time fMRI neurofeedback trial aimed at modulating the ventromedial prefrontal cortex (vmPFC)-amygdala pathway to control subjective anxiety and arousal.

Detailed description

The present randomized active-sham group controlled between-subject real-time fMRI neurofeedback trial aims at determining if (1) subjects can gain volitional control over the vmPFC-amygdala pathway involved in implicit emotion regulation and arousal by means of connectivity informed neurofeedback, (2) whether the training has specific effects on the behavioral and psychophysiological arousal level, and (3) or the amygdala or the vmPFC connectivity, respectively. The present project will determine the efficacy of the modulation of the vmPFC-amygdala functional connectivity pathway using vmPFC-amygdala upregulation (n = 25 subjects) compared to a sham control condition (targeting pathways not involved in emotion regulation, n = 20).

Conditions

• Emotion Regulation
• Healthy

Interventions

Type	Name	Description
DEVICE	Real-time fMRI neurofeedback from Turbo Brain voyager (TBV) 3.2	The two groups will undergo the same paradigm while learning to modulate the vmPFC -amygdala pathway and the sham pathway.

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-12-31
• Completion: 2025-03-31
• First posted: 2023-09-13
• Last updated: 2024-04-11

Locations

1 site across 1 country: China