Trials / Unknown
UnknownNCT06021262
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
Assessment of the Prognostic Value of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 90 (estimated)
- Sponsor
- Alexandria University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1. What are the prognostic values of neuroinflammatory markers? 2. What are the genotoxic effects of organophosphates? 3. what are the changes occurring in the levels of traditional oxidative stress and inflammatory markers?
Detailed description
This is a cross-sectional study that aims to assess the possible prognostic value of markers of neuroinflammation and nerve damage in patients with acute and chronic exposure to organophosphate pesticides by conducting a full proteomic and metabolomic profile. The possible genotoxic effect of common organophosphate pesticides will be studied as well. This will be conducted in parallel to the assessment of traditional markers of inflammation and oxidative stress. The target populations are patients with acute and chronic exposure to organophosphates with a total estimated number of 90 including individuals assigned to the control group with matched age and gender.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | exposure to organophosphates | organophosphates are esters of phosphoric acids or Thio phosphoric acids that exist in pesticides, where patients can be chronically or acutely exposed to such compounds. |
Timeline
- Start date
- 2023-08-01
- Primary completion
- 2023-12-01
- Completion
- 2024-01-01
- First posted
- 2023-09-01
- Last updated
- 2023-09-01
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT06021262. Inclusion in this directory is not an endorsement.