NCT06020534

Aortoiliac Stenosis in Kidney Transplantation

Safety and Efficacy of Kidney Transplantation in Patients With Aortoiliac Stenosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 655 (actual)
• Sponsor: Erasmus Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The impact of aortoiliac stenosis on kidney transplant patients remains unclear. This study aims to investigate the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis.

Detailed description

Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD). Unfortunately, not all ESRD patients are eligible for kidney transplantation. Aortoiliac stenosis, an increasingly common type of peripheral arterial disease in ESRD patients, is considered as relative contra-indication for kidney transplantation. There are several reasons for concern, such as the complexity of the vascular anastomosis and inferior life expectancy. Consequently, it is still debated whether patients with aortoiliac stenosis would benefit from kidney transplantation. This study aimed to supplement current literature on the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis. To achieve this, all patients undergoing kidney transplantation in Erasmus Medical Center between January 2010 and December 2020 were enrolled, and propensity score matching was used to minimize confounding factors. Additionally, long-term graft function was investigated to evaluate the impact of stenosis on graft function.

Conditions

• Aorto-Iliac Arterial Stenosis
• Peripheral Arterial Disease
• Kidney Transplant Failure

Timeline

• Start date: 2022-01-01
• Primary completion: 2023-01-31
• Completion: 2023-06-30
• First posted: 2023-08-31
• Last updated: 2025-01-07
• Results posted: 2024-12-12

Locations

1 site across 1 country: Netherlands