NCT06016049

Cerebral Changes Following CTS Treated With Guided Plasticity

Cerebral Changes Following Carpal Tunnel Syndrome Treated With Guided Brain Plasticity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

70 patients with mild to moderate Carpal tunnel Syndrome (CTS) including 24 patients with unilateral CTS were randomized to treatment with ipsilateral cutaneous forearm deafferentation with an anesthetic cream (EMLA®) or placebo during 8 weeks. Patient-rated outcomes was assessed using the symptom severity scale from the Boston carpal tunnel syndrome questionnaire (BCTQ) and the disability of arm, shoulder and hand questionnaire(Quick-DASH). Clinically patients were assessed for tactile discrimination and dexterity and nerve conduction studies (NCS). Cortical activation during sensory stimulation was evaluated with functional magnetic resonance imaging (fMRI) at 3T. Assessments were performed at baseline, after 90 min of initial treatment, and after 8 weeks.

Conditions

• Carpal Tunnel Syndrome

Interventions

Type	Name	Description
OTHER	EMLA® adjuvant	cutaneous forearm deafferentation
BEHAVIORAL	Sensory training	Sensibility training of the median nerve

Timeline

• Start date: 2009-07-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2023-08-29
• Last updated: 2023-08-29