NCT06000865

Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE

The GRADE Randomized Trial: Glaucoma Rehabilitation With Action viDeo Games and Exercise

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (estimated)
• Sponsor: The Hong Kong Polytechnic University · Academic / Other
• Sex: All
• Age: 55 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Falls are one of the most serious public health concerns for seniors, with significant medical and economic consequences. This concern is even higher in patients with peripheral field loss due to glaucoma because of the patients' compromised visual input. The investigators' project proposes an innovative, entertaining, easily accessible and enjoyable intervention for improving mobility and postural control function in glaucoma patients with peripheral vision loss, who are more prone to falls and suffer from fear of falling. The new intervention examined in this project can be implemented in current vision and balance rehabilitation programs, and may benefit patients with different types of visual impairment to minimize their risk of falls and improve their quality of life.

Detailed description

A prospective, 2-arm, randomized, single-blind, active-control trial will enroll 56 moderately- to severely-affected glaucoma patients with stable peripheral field loss, intact cognitive function, and no history of balance training. Participants will be randomly assigned 1:1 to one of two groups: 1) standing, physically interactive action video-game training (AVG\_PI); and 2) conventional physical training (PT). AVG using a Nintendo Switch gaming station will be administered in 20 sessions over 10 weeks (45 minutes per session, 2 sessions per week). Participants in the AVG\_PI will be in standing position with game controllers or sensors attached to the body while playing games involving muscle stretching and strengthening exercises. Participants in the PT will receive 45-minutes conventional physical training. Outcome measures will be assessed before training, and after 10 and 20 training sessions. The primary outcome measure is a test of mobility, and the secondary outcome measures include tests for dynamic balance plus visual cognition, static balance, visual cognition, and patient reported outcomes for fear of falling and quality of life.

Conditions

• Glaucoma
• Visual Impairment

Interventions

Type	Name	Description
BEHAVIORAL	Action video game training	20 sessions of AVG over 10 weeks (45 minutes per session, 2 sessions per week)
BEHAVIORAL	Conventional physical training	20 sessions of physical training over 10 weeks (45 minutes per session, 2 sessions per week)

Timeline

• Start date: 2023-09-09
• Primary completion: 2025-07-30
• Completion: 2025-12-30
• First posted: 2023-08-21
• Last updated: 2025-07-28

Locations

1 site across 1 country: Hong Kong