NCT05999526

Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial

Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial: a Randomized Controlled Feasibility Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Centro Hospitalar Unimed de Joinville · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the feasibility to perform a future larger clinical trial to analyze whether the mechanical ventilation reconnection for 1 hour after a successful spontaneous breathing trial reduces the risk of reintubation or death at 7 days in participants with more than 72 hours of mechanical ventilation. The study will compare two weaning strategies in critically ill participants admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial: 1. Reconnection to mechanical ventilation for 1 hour followed by extubation; 2. Direct extubation. Follow-up will be until hospital discharge or death.

Conditions

• Airway Extubation
• Ventilator Weaning

Interventions

Type	Name	Description
OTHER	Reconnection to mechanical ventilation for 1 hour	As soon as the success of the spontaneous breathing trial is confirmed, the participant will be kept on the mechanical ventilator for 1 hour using the previous ventilatory parameters and, afterwards, extubated.
OTHER	Direct extubation	The participant will be extubated immediately after the spontaneous breathing trial.

Timeline

• Start date: 2023-11-02
• Primary completion: 2024-03-22
• Completion: 2024-06-15
• First posted: 2023-08-21
• Last updated: 2025-02-17

Locations

1 site across 1 country: Brazil