NCT05997173

The Regulatory Role of Immune Response in Oral Lichen Planus

The Regulatory Role of Immune Response in Oral Lichen Planus With Mental Disorders

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it. In vitro, previous studies have shown that oral mucosal mesenchymal stem cell cells (MSCs) can secrete Ido, which is involved in the pathogenesis of OLP. It has been proved that mental disorders such as depression and anxiety play an important role in the pathogenesis and treatment of OLP. Mental stress factors can cause abnormal changes of inflammatory factors, leading to immune dysfunction, which is also one of the main causes of OLP. In this study, we integrated the advantages of stomatology, psychiatry, neurobiology and traditional Chinese medicine, focused on the clinical problems of mental disorders with oral mucosal comorbidity, and assessed the depressive and anxiety status of OLP patients, so as to improve the therapeutic effect of OLP.

Conditions

• Oral Lichen Planus

Interventions

Type	Name	Description
OTHER	Control	Investigation of scale of control
OTHER	Non erosive OLP	Investigation of cale of non erosive OLP patients
OTHER	Erosive OLP	Investigation of cale of erosive OLP patients

Timeline

• Start date: 2020-09-07
• Primary completion: 2025-02-01
• Completion: 2025-02-01
• First posted: 2023-08-18
• Last updated: 2023-08-18

Locations

1 site across 1 country: China