NCT05992337

New Biomarkers in the Prediction of Chemotherapy-induced Cardiotoxicity.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Cardiology Prague · Network
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Early detection and thus rapid therapy of cardiotoxicity related to chemotherapy are essential for restoring cardiovascular function. The complete recovery of the cardiovascular system decreases with time to identify the presence of cardiotoxic damage. The project aims to define new biomarkers for the early detection of cardiotoxicity in patients treated with chemotherapy.

Detailed description

The most effective approach to minimizing the consequences of cardiotoxicity of oncological treatment is its early identification, adjustment of oncological treatment (change of procedure, dose, drugs), and immediate initiation of cardiovascular therapy. However, the current standard for monitoring the cardiovascular system in cancer patients identifies cardiotoxicity only if functional impairment has already occurred, which precludes any chance of effective prevention. The aim of the project is to identify new biomarkers for the early detection of the cardiotoxic effect of chemotherapy in women with breast cancer.

Conditions

• Cardiotoxicity
• Chemotherapy Effect
• Chemotherapy Induced Systolic Dysfunction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood sampling	Blood sample collection for mRNA determination
DIAGNOSTIC_TEST	Echocardiography	Echocardiography for detection of ventricular dysfunction
DIAGNOSTIC_TEST	Cardio MRI	MRI for early detection of myocardial impairment caused by chemotherapy
DIAGNOSTIC_TEST	24-hours monitoring of ECG	Diagnostic test for detection of arrhythmias as a consequence of cardiotoxicity
DIAGNOSTIC_TEST	24 hours monitoring of BP	Diagnostic test for detection of hypertension as a consequence of cardiotoxicity

Timeline

• Start date: 2021-09-01
• Primary completion: 2024-11-01
• Completion: 2025-01-01
• First posted: 2023-08-15
• Last updated: 2023-08-16

Locations

2 sites across 1 country: Czechia