NCT05974501

Pre vs Post Block in Total Knee Arthroplasty (TKA)

Pre vs. Postoperative Adductor Canal Block for Total Knee Arthroplasty: Prospective Randomized Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee arthroplasty can be observed with the substitution of a post operative adductor canal block for a preoperative adductor canal block in the current established peri-operative pain protocol and if these changes lead to a decrease in opioid consumption (in morphine equivalents).

Conditions

• Knee Osteoarthritis
• Arthroplasty Complications
• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Dexamethasone	Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling
DRUG	Acetaminophen	1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively
DRUG	Lyrica	Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively
DRUG	Celebrex	200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively
DRUG	Meloxicam	30mg administered via IV once postoperatively within 24 hours for pain and swelling
DRUG	Oxycodone	5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively
DRUG	Ropivacaine	20 milliliters Ropivacaine 0.2% administered via injection perioperatively.

Timeline

• Start date: 2023-09-29
• Primary completion: 2024-01-22
• Completion: 2024-01-22
• First posted: 2023-08-03
• Last updated: 2025-02-12
• Results posted: 2025-02-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study