NCT05973097

Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy

Clinical Study of Combined Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 156 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and is considered a precancerous condition. It is characterized by white reticular changes in the oral mucosa, which can progress to erosions and cause pain in severe cases. The pathogenesis of OLP is still unclear, but it is believed to be a T-lymphocyte-mediated autoimmune disease. Currently, only symptomatic treatments are available, and there is no definitive cure. In this project, we plan to use TCM differentiation to categorize OLP patients and conduct a randomized controlled clinical trial to demonstrate the enhanced therapeutic effect of paeoniflorin combined with photodynamic therapy for OLP. The implementation of this project will provide new insights into the clinical management of OLP, improve our understanding of the treatment mechanisms, and have important theoretical and clinical implications.

Detailed description

Paeoniflorin, a compound extracted from the traditional Chinese medicine, has anti-inflammatory and immunomodulatory effects. Photodynamic therapy is a novel local treatment approach, where photosensitizers selectively target and destroy diseased cells. Both treatments have shown efficacy in treating OLP when used individually.

Conditions

• Oral Lichen Planus

Interventions

Type	Name	Description
DRUG	total glucosides of paeony treatment	Total glucosides of paeony capsules were given 0.6 g once, 3 times a day.
OTHER	photodynamic therapy treatment	Cover the lesion with photosensitizer and fix it. Remove the photosensitizer and treat with laser diode.
OTHER	glucosides of paeony and photodynamic therapy combined treatment	Glucosides of paeony and photodynamic therapy are combined for the treatment

Timeline

• Start date: 2023-07-30
• Primary completion: 2028-12-30
• Completion: 2028-12-30
• First posted: 2023-08-02
• Last updated: 2023-08-02

Locations

1 site across 1 country: China