NCT05972577

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Optimization of Older Adult Allogeneic Hematopoietic Cell Transplant Candidates to Improve Survival (OTIS)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Ohio State University Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial tests whether a geriatric optimization plan (GO!) works to improve survival in patients over 60 with a hematologic malignancy or bone marrow failure syndrome eligible for allogeneic hematopoietic cell transplant. GO! focuses on creating a tailored and specific plan for each patient to make changes in their daily lives. These may include changes to their diet, sleep, activity, medicines, or even referrals to other providers depending on the patient's needs. Studying survival and quality of life in patients over 60 receiving an allogeneic hematopoietic cell transplant may help identify the effects of treatment.

Detailed description

PRIMARY OBJECTIVE: I. To demonstrate that geriatric assessment with management (GAM) intervention will lead to improved physical functioning in allogeneic hematopoietic cell transplant (allo-HCT)-eligible older adults as measured by improvement in 6-Minute Walk Test distance of at least 35 meters. SECONDARY OBJECTIVES: I. To demonstrate that GAM intervention will result in improvement in Short Physical Performance Battery score by at least 1 point or score will remain \>= 10 for those with baseline scores \>= 10. II. To demonstrate that GAM intervention will result in improvement in Mini Nutritional Assessment score by at least 2 points or score will remain \>= 12 for those with baseline scores \>= 12. III. To evaluate change in cognition and mental health as measured by Montreal Cognitive Assessment, Personal Health Questionnaire-9, Generalized Anxiety Disorder-7, and Transplant Evaluation Rating Scale score before and after GAM intervention. IV. To determine cumulative incidence rate for receipt of allo-HCT among study participants. V. To measure overall survival and non-relapse mortality among study participants. VI. To assess self-reported adherence to prescribed interventions. VII. To measure change in patient-reported quality of life immediately following GAM intervention and up to one year after completion of intervention. EXPLORATORY OBJECTIVES: I. To describe patterns of sleep and activity among study participants during intervention period based on accelerometer data. II. To understand transplant physician rationale for not proceeding to allo-HCT for older patients with eligible diagnoses. OUTLINE: Patients undergo personalized Geriatric Optimization (GO!) plan consisting of study visits over 50 minutes at baseline and 6 months after first visit or at the time of hospital admission for bone marrow transplant and over 25 minutes at 3 and 12 months after transplant. Patients complete questionnaires once a month for up to 6 months and wear an accelerometer for up to 6 months.

Conditions

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Aplastic Anemia
• Chronic Lymphocytic Leukemia
• Chronic Myelogenous Leukemia, BCR-ABL1 Positive
• Hematopoietic and Lymphoid Cell Neoplasm
• Hodgkin Lymphoma
• Myelodysplastic Syndrome
• Myelofibrosis
• Myeloproliferative Neoplasm
• Non-Hodgkin Lymphoma
• Plasma Cell Myeloma

Interventions

Type	Name	Description
OTHER	Health Promotion and Education	Undergo GO!
OTHER	Medical Device Usage and Evaluation	Wear accelerometer
OTHER	Quality-of-Life Assessment	Complete quality of life assessments and diary entries
OTHER	Questionnaire Administration	Complete questionnaires

Timeline

• Start date: 2021-06-11
• Primary completion: 2024-11-13
• Completion: 2024-11-13
• First posted: 2023-08-02
• Last updated: 2026-04-06

Locations

1 site across 1 country: United States