NCT05967390

Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)

Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE): A Project of MRI-informed Computational Head Model

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 488 (estimated)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 60 Years – 95 Years
• Healthy volunteers: Accepted

Summary

Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.

Detailed description

Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.

Conditions

• Aging
• Dementia Alzheimers
• Parkinson Disease
• Dementia Frontotemporal
• Depression in Old Age

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation	One time for each day, lasting for three weeks.

Timeline

• Start date: 2023-06-15
• Primary completion: 2024-12-14
• Completion: 2025-06-14
• First posted: 2023-08-01
• Last updated: 2025-01-14

Locations

1 site across 1 country: Hong Kong

Regulatory

• FDA-regulated device study