NCT05966454

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR) -A Randomized Controlled Trial

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 145 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis

Detailed description

This is a single center, randomized controlled trial to determine if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Conditions

• Appendicitis

Interventions

Type	Name	Description
DRUG	Multiple standard of care antibiotics for appendicitis, at physicians' discretion	Standard of Care Antibiotic use will be restricted to none or up to 24 hours of post-operative antibiotics.
DRUG	Multiple standard of care antibiotics for appendicitis, at physicians' discretion	Standard of Care Antibiotic use will be permitted for 24 hours or up to 4 days of post-operative antibiotics.

Timeline

• Start date: 2023-06-06
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2023-07-28
• Last updated: 2025-05-08

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study