NCT05965843

Intervention, Prognosis and Mechanism of Covid-19 Infection in Patients With Underlying Diseases

Research on the Intervention, Prognosis and Mechanism of Novel Coronavirus Infection in Patients With Underlying Diseases

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 480 (estimated)
• Sponsor: The Second Affiliated Hospital of Chongqing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to explore the influence of Covid-19 infection and risk factors of severe outcomes in vulnerable population including patients with chronic liver disease, malignant tumor, autoimmune disease, medical staff. The main questions it aims to answer are: 1. The clinical characteristics of vulnerable population after Covid-19 infection. 2. Risk factors for severe illness in vulnerable groups after infection with the Covid-19. 3. The impact of Covid-19 infection on the progression of underlying diseases. Information of participants will be collected such as gender, age, underlying diseases, medication status, vaccination status, clinical and biochemical indicators. Researchers will compare the mild and severe outcomes after Covid-19 infection to identify the "truly vulnerable" population and explore the potential mechanism and intervention for these population.

Conditions

• Chronic Liver Disease
• Malignant Tumor
• Autoimmune Diseases
• Healthy

Interventions

Type	Name	Description
OTHER	underling disease	Nowadays Covid-19 virus has become milder than before however severe outcomes still happen in people with underlying diseases after infection. For example, previous research indicated cirrhosis was an independent predictor for COVID-19 mortality. More efforts shoud be make to explore the association between underlying diseases and severe COVID-19.

Timeline

• Start date: 2023-08-01
• Primary completion: 2023-12-01
• Completion: 2024-12-01
• First posted: 2023-07-28
• Last updated: 2023-08-03