NCT05961371

Strength Training for Osteoporosis Prevention During Early Menopause

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Calgary · Academic / Other
• Sex: Female
• Age: 45 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical pilot trial is to learn about the feasibility of a high-intensity resistance training intervention in peri- and early menopausal females. The main question it aims to answer are: -Is a 9-month resistance training intervention feasible (e.g., recruitment rates, protocol adherence, attrition) Secondary aims include examining changes in bone health, muscle strength, and menopausal symptoms. Participants will participate in a 9-month progressive, supervised, resistance training intervention. Researchers will compare secondary outcomes between the exercise group and a wait-list control group.

Detailed description

The STOP-EM trial will examine a 9-month supervised, progressive, resistance training program in peri- and early menopausal females. Primary outcomes include recruitment rates, protocol adherence, and attrition. A waitlist control group will allow us to examine the effect of the exercise program on bone density, structure, and strength, muscle strength, and menopausal symptoms. Participants will be randomized to the exercise or control group. The exercise group will attend twice weekly, in-person, supervised, progressive resistance training and build up to 80-90% of estimated 1 repetition maximum (1RM). The study will take place at the University of Calgary. Findings will be used to decide whether to continue to the definitive trial.

Conditions

• Bone Loss
• Bone Loss, Age-related
• Osteoporosis
• Musculoskeletal Diseases

Interventions

Type	Name	Description
OTHER	Resistance Training	Twice weekly resistance training progressing to 5 sets of 5 repetitions of 80-90% of one repetition maximum.

Timeline

• Start date: 2023-11-01
• Primary completion: 2025-02-01
• Completion: 2025-06-01
• First posted: 2023-07-27
• Last updated: 2024-12-05

Locations

1 site across 1 country: Canada