NCT05957003

Fluid Responsiveness in Post-cardiac Surgery

The Validity of Combined End-expiratory and End-inspiratory Occlusion Test and Tidal Volume Challenge Test for Prediction of Fluid Responsiveness in Immediate Post-cardiac Surgery Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

the study aims to examine the validity of combined end-expiratory and end-inspiratory occlusion test and tidal volume challenge test for prediction of fluid responsiveness in immediate post-cardiac surgery patients

Detailed description

multiple studies prove that dynamic variables based on heart-lung interactions accurately can predict fluid responsiveness in mechanically ventilated patients, including pulse pressure variation (PPV) and stroke volume (SV) variation. Furthermore, passive leg raising (PLR), end-expiratory occlusion test, and tidal volume challenge test, "Mini"-fluid challenge are currently available to assess fluid responsiveness.

Conditions

• Fluid Overload
• Cardiac Surgery
• Postoperative Complications

Interventions

Type	Name	Description
PROCEDURE	Combined end-expiratory occlusion and end-inspiratory occlusion test	The EEO test will be performed by interrupting the mechanical ventilation at end-expiration over 15 seconds using the end-expiratory hold button available on the ventilator. The EIO test will be performed by interrupting the mechanical ventilation at end-inspiration over 15 seconds using the end-inspiratory hold button available on the ventilator.
PROCEDURE	Tidal volume challenge test	elevating tidal volume from 6 ml/kg to 8 ml/kg for only 60 seconds

Timeline

• Start date: 2023-08-10
• Primary completion: 2025-08-20
• Completion: 2025-09-01
• First posted: 2023-07-24
• Last updated: 2025-11-25

Locations

1 site across 1 country: Egypt