NCT05956067

Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Participants with chronic pain conditions including chronic low back pain and fibromyalgia may benefit from light stimuli presented to the retina to reduce chronic pain severity and pain sensitivity. Participants will be recruited into this study and will be presented with one of three uniform light stimuli via a wide-field ganzfeld in three conditions to determine the retinal mechanisms that reduce pain. This work will lead to a greater understanding of retinal mechanisms that contribute to pain and will assist the design of future studies to harness the potential of light based pain therapies.

Conditions

• Chronic Low-back Pain
• Chronic Pain
• Fibromyalgia

Interventions

Type	Name	Description
DEVICE	Green Light stimulation	A portable battery-operated ganzfeld light display will be used to deliver green light for 2 hours per day for 5 consecutive days.
DEVICE	Equal Energy White stimulation	A portable battery-operated ganzfeld light display will be used to deliver white light for 2 hours per day for 5 consecutive days.
DEVICE	S-cone modulating white light	A portable battery-operated ganzfeld light display will be used to deliver S-cone modulating light for 2 hours per day for 5 consecutive days.

Timeline

• Start date: 2023-08-25
• Primary completion: 2026-07-17
• Completion: 2026-07-29
• First posted: 2023-07-21
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study