NCT05951972

Characterization of Small Molecule Profiles in the Healthy Human Gastrointestinal Tract

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: Eran Elinav · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study will assess global small molecule profiles identified in the human gastrointestinal tract of healthy human volunteers.

Detailed description

The gut is home to an extensive interaction between the host and its microbiota, in different regions exposed to endogenous and exogenous signals, such as nutrition, medications, immune alterations, and geographical location-related factors. this study aims to characterize the small molecule profiles of a cohort of healthy individuals, including their polar, semi-polar, non-polar, and protein landscape. The investigators will develop a pipeline enabling to integrate these small molecule profiles with a variety of inter-individual readouts, as assessed in stools of healthy volunteers. Data will be used to characterize molecular patterns potentially associated with a variety of dietary, immune, and health-related human features, with an aim to characterize small molecules for future causative investigation.

Conditions

• Nutrition, Healthy

Interventions

Type	Name	Description
OTHER	nutritional	participants will receive 2 pairs of food items to consume - pair A - Bananas and Apples, pair B - cucumbers and peanuts.

Timeline

• Start date: 2023-04-15
• Primary completion: 2025-04-01
• Completion: 2025-08-01
• First posted: 2023-07-19
• Last updated: 2025-09-09

Locations

1 site across 1 country: Israel