NCT05941624

Comparison Between HA330 Hemoperfusion Filter Hemodialysis and Conventional High-Flux Hemodialysis Filter

Comparison Between HA330 Hemoperfusion Filter Hemodialysis and Conventional High-Flux Filter Hemodialysis in Reducing Inflammatory Mediators in Renal Dysfunction Due to Sepsis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the effectiveness between conventional hemodialysis and hemodialysis using hemoperfusion adsorbents in renal dysfunction caused by sepsis

Detailed description

This study is an open randomized clinical trial. Data were taken prospectively until the number of samples was fulfilled for analysis. Due to the intervention provided, this study was not blinded. Subjects were divided into 2 groups (group undergoing conventional hemodialysis and group undergoing HA330 hemoperfusion). Both groups underwent therapy for 4 hours, 3 times a week, with two days apart between dialysis. Inflammatory mediator levels were assessed 4 times, before and after each intervention. All subjects were given standard therapy as indicated such as antibiotics, oxygen supplementation, administration of vasopressors, nutrition, and other therapies as indicated.

Conditions

• Renal Dysfunction
• Sepsis
• Hemodialysis

Interventions

Type	Name	Description
DEVICE	Ha-330 Hemoperfusion Filter Hemodialysis	a total of 4 hours therapy, 3 times a week. Each therapy should be two days apart
DEVICE	Conventional Hemodialysis	a total of 4 hours therapy, 3 times a week. Each therapy should be two days apart

Timeline

• Start date: 2023-06-16
• Primary completion: 2023-12-31
• Completion: 2024-03-31
• First posted: 2023-07-12
• Last updated: 2025-05-02

Locations

1 site across 1 country: Indonesia