NCT05920083

Obstructive Sleep Apnea - Autonomic and Vascular Exploration

Noctural Pulse Waves Variations in OSA as a Predictor of Autonomic and Vascular Response to CPAP Therapy

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: Raphael Heinzer · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to assess the effect of CPAP withdrawal on vascular and autonomic function in patients with obstructive sleep apnea. The main question it aims to answer is: • Is the pulse wave amplitude index able to predict the impact of sleep apnea treatment withdrawal (continuous positive airway pressure, CPAP) on endothelial function and baroreflex sensitivity? Participants will stop using their CPAP for 2 weeks and the investigators will assess vascular and autonomic function before and after the withdrawal. Researchers will compare endothelial and autonomic function at baseline and after 2 weeks of withdrawal to see if there are differences. Moreover, they will assess the association between pulse wave amplitude drop profile and effect of CPAP withdrawal.

Conditions

• Obstructive Sleep Apnea

Interventions

Type	Name	Description
OTHER	CPAP withdrawal	2 weeks of CPAP withdrawal

Timeline

• Start date: 2024-01-12
• Primary completion: 2024-09-11
• Completion: 2024-09-11
• First posted: 2023-06-27
• Last updated: 2025-12-12

Locations

1 site across 1 country: Switzerland