NCT05919901

Multi-level School-based Intervention to Improve HPV Vaccine Uptake and Completion in South Africa

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 9 Years – 12 Years
• Healthy volunteers: Accepted

Summary

Human Papillomavirus (HPV) is the most common sexually transmitted infection globally, and is causally linked to cervical, anogenital, and oropharyngeal cancers. HPV-associated cancers have a disproportionate impact in low-resource settings and nowhere is this evident than in South Africa, which has a uniquely vulnerable population due to the convergence of the largest HIV epidemic globally, with HPV rates of up to 85% in young women under the age of 25. For the clinical trial phase of this study, we intend to evaluate preliminary effects of a communications strategy and key criteria to advance to a full scale hybrid type 2 trial. Our systems-focused approach leverages established partnerships with area schools serving diverse populations who are not always effectively served by traditional healthcare channels.

Conditions

• HPV

Interventions

Type	Name	Description
OTHER	HPV Vaccine Communication Strategy	The intervention will include health promotions materials and provision of HPV vaccine

Timeline

• Start date: 2024-07-26
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2023-06-26
• Last updated: 2025-10-31

Locations

1 site across 1 country: South Africa